Characterizing DNA methylation signatures and their potential functional roles in Merkel cell carcinoma
Abstract Background Merkel cell carcinoma (MCC) is a rare but aggressive skin cancer with limited treatment possibilities.Merkel cell tumors display with neuroendocrine features and Merkel cell polyomavirus (MCPyV) infection in the majority (80%) of patients.Although loss of histone H3 lysine 27 trimethylation (H3K27me3) has been shown during MCC t